Duration of supplementation depends on the degree of destruction of cartilage and the patient's age, but should not be less than 2-3 months. The extract of shark cartilage, Shark Rei Formula (Shark Ray Formula) contains mucopolysaccharides and glycosaminoglycan. One of the components of shark cartilage is chondroitin sulfate, which in this preparation is 200 times larger than glucosamine sulfate. Another component of this formula is Reishi mushroom is rich in polysaccharides, has a strong effect immunnomoduliruyuschee. Recommended dose – 3-5 capsules 3 times daily with meals. However, individual vitamins, minerals, herbs and potentiate the effect of glucosamine sulfate, increasing its efficiency.

Since vitamin C (Vitamin C) plays an important role in the synthesis of collagen, the connective tissue regeneration. It normalizes capillary permeability, improves nutrient delivery to the hearth lesions, reduces swelling of tissues. As an antioxidant, vitamin C destroys free radicals, prolong the life of other antioxidants, including vitamin E and glutathione. Appointment of vitamin C is required in treatment and prevention of OA. Recommended dose – 1,000 to 3,000 mg per day during the time of treatment. Vitamin E (Vitamin E) relieves the pain of OA sufferers, has an effective antioxidant that inhibits enzymes that break down cartilage and enhances its regeneration.

Recommended dose – 400 to 800 IU per day during the time of treatment. Omega 3 (omega 3) polyunsaturated fatty acids – eicosapentaenoic acid (EPA) and dekozageksaenovaya acid (DHA). These substance that results in anti-inflammatory prostaglandins. In addition, they can replace NAFP and painkillers. Of course, they do not have such a quick action as NAFP, but the side effects of their admission is not observed.