Diabetes Control

Parallel, they presented reduction in peptdeo-C of jejum, increase in the dose of insulina and the HbA1c in relation to those during the first year of diagnosis. Other studies in this felt they had shown a heterogeneidade in the results, perhaps related to the level of the glicmico control of the patients. Therefore all the studies, however, suggest that the glicotoxicidade is responsible for a great parcel of LAUGHS in the DM1. (DINIZ, 2002) Corroborating with this hypothesis, a recent study, using the technique of clamp euglicmico, it showed a significant correlation enters the resistance to the insulina and the degree of hiperglicemia (glicotoxicidade) evaluated by the value of the HbA1c in patients with DM1 of recent diagnosis. In the study of the DCCT (Diabetes Control and Complications Trial), the values of HbA1c, gotten in the adolescents, had been on average 1% superior to the obtained one in the adults, as much in the group in conventional treatment as in intensive, although to be receiving more insulina (units for kilo of weight). The triad high values of HbA1c, necessities of bigger insulina and exaggerated profit of weight in the DM1, suggests that the managed insulina is being little effective in controlling the glicemia (resistance to the insulina). BRAZIL (2002) tells that diabetes mellitus type 1 is a syndrome of multiple etiology, resultant of the relative or absolute deficiency in the production of insulina for the pncreas and/or of the incapacity of this hormone to exert its effect adequately, resulting in chronic hiperglicemia and alteration in the metabolism of the carboidratos of lipdios and proteins, being able, in the long run, to occur disfunes in some agencies. One of the important hormonais factors that lead to the increase of the resistance to the insulina in the DM1 is the growth hormone secretion exaggerated during the puberty. The insulina, managed subcutaneously, exceeds the circulation vestibule, what it provokes a reduction in its intra-heptico effect.